CONSIDERATIONS TO KNOW ABOUT NR1-SITE

Dependant upon its subunit composition, its ligands are glutamate and glycine (or D-serine). Nevertheless, the binding from the ligands is often not adequate to open the channel as it could be blocked by Mg2+ ions which might be only eradicated if the neuron is adequately depolarized. So, the channel acts being a "coincidence detector" and only onc